Torsemide is absorbed more completely than furosemide when taken by mouth.
Correct Answer
True
True. Oral furosemide absorption is incomplete and varies between patients, while torsemide is absorbed more predictably, which can make its effect more consistent.
Category: Loop Diuretics
Question 2
NSAIDs can reduce the diuretic and antihypertensive effects of furosemide.
Correct Answer
True
True. NSAIDs block prostaglandins that help maintain kidney blood flow and sodium excretion, so the diuretic response falls and kidney function can worsen.
Category: Loop Diuretics
Question 3
Hydrochlorothiazide is contraindicated in a patient with hypersensitivity to sulfonamide-derived drugs.
Correct Answer
True
True. Hydrochlorothiazide is a sulfonamide derivative, and its labeling lists hypersensitivity to sulfonamide-derived drugs as a contraindication; the nurse checks the allergy history before the first dose.
Category: Thiazide Diuretics
Question 4
Mannitol should not be given at the same time as blood products through the same administration set.
Correct Answer
True
True. Mannitol mixed with blood can cause clumping of red cells called pseudoagglutination, so the two are not given together through one set.
Category: Osmotic Diuretics
Question 5
Long-term hydrochlorothiazide use has been linked to an increased risk of nonmelanoma skin cancer.
Correct Answer
True
True. Labeling warns of a higher risk of basal cell and squamous cell skin cancer with cumulative use, so patients are taught sun protection and regular skin checks.
Category: Thiazide Diuretics
Question 6
Spironolactone is used to treat edema caused by liver cirrhosis.
Correct Answer
True
True. Cirrhosis activates the renin-angiotensin-aldosterone system, and spironolactone blocks aldosterone to reduce the sodium and water retention behind edema and ascites.
Category: Potassium-Sparing Diuretics
Question 7
Acetazolamide makes the urine more alkaline.
Correct Answer
True
True. By blocking bicarbonate reabsorption, acetazolamide leaves more bicarbonate in the urine, raising its pH while blood bicarbonate falls.
Category: Carbonic Anhydrase Inhibitors
Question 8
Mannitol is filtered at the glomerulus but is reabsorbed very little by the renal tubules.
Correct Answer
True
True. Because mannitol stays in the tubular fluid, it raises the osmotic pressure there and holds water in the tubule, so more water and sodium leave in the urine; this is also why the drug needs urine-producing kidneys to work.
Category: Osmotic Diuretics
Question 9
Loop and thiazide diuretics can raise blood cholesterol and triglyceride levels.
Correct Answer
True
True. Both classes can increase total cholesterol, LDL and triglycerides, so lipid levels are followed in patients on long-term therapy.
Category: Diuretic Nursing Care
Question 10
Older adults taking diuretics have a higher risk of falls.
Correct Answer
True
True. Orthostatic hypotension, urgent and frequent urination, and electrolyte shifts that affect thinking and muscle strength all raise fall risk, so safety teaching is part of diuretic care.
Category: Diuretic Nursing Care
Question 11
Spironolactone is a safe choice for a patient with Addison disease.
Correct Answer
False
False. Addison disease is a contraindication to spironolactone, because a patient who already lacks aldosterone is prone to hyperkalemia and blocking aldosterone receptors worsens it.
Category: Potassium-Sparing Diuretics
Question 12
Potassium-sparing diuretics produce a stronger diuresis than loop diuretics.
Correct Answer
False
False. Potassium-sparing diuretics act where only a small share of sodium is reabsorbed, so their diuresis is weak; they are usually paired with stronger diuretics to protect potassium.
Category: Potassium-Sparing Diuretics
Question 13
Raising a loop diuretic dose above its ceiling dose keeps increasing urine output.
Correct Answer
False
False. The ceiling dose is the point beyond which more drug produces no additional diuresis, so larger doses only add adverse effects such as ototoxicity.
Category: Diuretic Nursing Care
Question 14
Metolazone loses its diuretic effect once kidney function is reduced.
Correct Answer
False
False. Unlike many thiazides, metolazone remains effective in patients with chronic kidney disease, which is one reason it is paired with loop diuretics in resistant edema.
Category: Thiazide Diuretics
Question 15
Acetazolamide commonly raises serum potassium.
Correct Answer
False
False. Acetazolamide increases potassium loss in the urine and can cause hypokalemia, and existing low potassium or sodium is a contraindication to the drug.
Category: Carbonic Anhydrase Inhibitors
Question 16
Furosemide can be given only by the intravenous route.
Correct Answer
False
False. Furosemide can be given by mouth, intramuscularly and intravenously, with IV use reserved for rapid or reliable effect.
Category: Loop Diuretics
Question 17
Acetazolamide produces a stronger diuresis than furosemide.
Correct Answer
False
False. Acetazolamide is a weak diuretic whose effect fades as metabolic acidosis develops; furosemide and the other loop diuretics are the most potent class.
Category: Carbonic Anhydrase Inhibitors
Question 18
Loop diuretics stop working in chronic kidney disease, so they are avoided in these patients.
Correct Answer
False
False. Loop diuretics remain effective when GFR is reduced and are widely used to control fluid overload in chronic kidney disease, although larger doses may be needed.
Category: Loop Diuretics
Question 19
Diuretic braking is a progressive increase in urine output with repeated doses of a loop diuretic.
Correct Answer
False
False. Diuretic braking is a progressive decline in response to repeated loop diuretic doses, as the body activates sodium-retaining mechanisms and the distal tubule reabsorbs more sodium.
Category: Diuretic Nursing Care
Question 20
Mannitol is taken by mouth to lower intracranial pressure.
Correct Answer
False
False. Mannitol for intracranial or intraocular pressure is given intravenously, and the nurse watches the infusion site closely because extravasation can injure tissue.
Category: Osmotic Diuretics